To Be Successful in Business, You Have to Be Contrarian and Right

To Be Successful in Business, You Have to Be Contrarian and Right

Evan Nisselson first met Roelof Botha, Managing Partner and Steward of Sequoia Capital, while fundraising for his startup in 2005. Roelof said, “I think back to that meeting we had, and you had a vision for the future and the impact of visual, just imagery on consumer experiences was completely spot on.

At our 10th Annual LDV Vision Summit, Roelof joined Evan for a fireside chat to discuss trends and early-stage investment opportunities in businesses leveraging visual technologies and AI. They spoke about Roelof’s insights from the ups and downs of the PayPal days, marshmallow tests, personality traits and much more!

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AI in Neuroscience: Partnering with DANNCE.AI to Increase Drug Efficacy & Improve the Lives of People with Movement Disorders

Many of us know someone affected by Parkinson's or another movement disorder, and we’ve seen the challenges they face. Treatment for these conditions varies widely, depending not only on the specific diagnosis but also on how accurately symptoms are measured and monitored over time. Precise tracking of symptoms is essential to tailoring treatments effectively, helping doctors and patients better understand disease progression and response to therapies. 

Clinicians currently lack tools for objective patient movement evaluation. They manually rate impairment on a 0-4 scale, leading to inconsistent scoring across doctors. This variability hinders clinical decisions and complicates assessing therapeutic efficacy. Advances in AI technology are now enabling more accurate, real-time tracking, paving the way for more personalized and effective care for those with movement disorders.

DANNCE.AI is bringing to market a novel phenotyping platform to digitize the clinical assessments used by clinicians and drug developers to quantify movement. DANNCE is a new approach to the clinical exam that ingests videos of patients and automatically analyzes them for evidence of neurological disease. The platform can also evaluate the efficacy of drugs for patients with neurological disorders.

Team (from left to right): Tim Dunn (Chief Scientific Officer & co-founder), Suraj Dhulipalla (Software Engineer), Shereen Shermak (Chief Operating Officer), Rebekah Griesenauer (Head of Data), Joe Chan (Chief Technology Officer), Rob Baldoni (Chief Executive Officer & co-founder), Jesse Marshall (co-founder). Photo taken in September 2024 outside the team’s office in Cambridge, Massachusetts.

The DANNCE platform has the potential to serve as both an endpoint for drug development and as an automated clinical assessment. The total addressable market as an endpoint and diagnostic for movement disorders and relevant neuropsychiatric indications (e.g. Autism, ADHD) is a $20B opportunity. Additionally, the economic burden of movement disorders and neuropsychiatric disease is over $2T, and the use of DANNCE in an upstream setting to better diagnose patients and to better manage them would also enable tremendous cost savings.

At LDV Capital, we invest in people building businesses powered by visual technology & artificial intelligence. We are thrilled to partner with the brilliant deep tech team at DANNCE.AI to leverage advanced computer vision solutions to increase drug efficacy and significantly improve the lives of people with movement disorders. We thrive on investing in people building innovative solutions that enhance people’s lives and provide substantial value. 

We led their $2.6M pre-seed round along with co-investors Glasswing Ventures, The Leo Lion Company, Duke Capital Partners, and Merck Digital Sciences Studio.

DANNCE will deliver comprehensive quantifications of behavior and body mechanics, which will be feasible to implement in the clinic for the first time. DANNCE uses AI to reconstruct a patient's movement in 3D using videos from multiple cameras and transforms the data into quantified, easy-to-interpret readouts of movement and behavior. DANNCE can be used to diagnose patients, calculate the severity of their impairments, and monitor their change over time. This represents a paradigm shift from the current standard of care, which relies on clinicians to administer and score subjective assessments. DANNCE’s behavioral quantification workflow, built on top of markerless pose tracking, recapitulates doctors’ findings and unlocks inaccessible clinical insights by analyzing gross and fine movement.

DANNCE.AI’s technology originated at Harvard University, where Dr. Tim Dunn and Dr. Jesse Marshall met as postdocs in 2016 while studying the neuronal control of movement in rats. Noticing a lack of tools to measure movement accurately, they, along with Prof. Bence Ölveczky and Diego Aldarondo, invented DANNCE to understand how drugs modulate movement circuits. Tim later became a faculty member at Duke, where he further advanced the platform and met Rob Baldoni, one of his first students, who would lead the commercialization of the technology. 

In August 2024, Rob and the team licensed the DANNCE platform from both universities with the goal of transitioning the technology from academic to clinical use. Dr. Tim Dunn (CSO) and Dr. Jesse Marshall (Advisor) are DANNCE.AI’s co-founders, along with Rob Baldoni (CEO), who was featured in the Boston Business Journal’s 2024 list of 25 Under 25.

“One in ten individuals will be diagnosed with a movement disorder during their lifetime. We are creating a world where aging adults have broad access to objective neurological screenings and new therapies for these disorders are also objectively validated,” says Rob Baldoni, CEO and co-founder of DANNCE.AI. “We have brought together a powerhouse team with Tim and Jesse, two of the world’s leading experts in behavioral quantification, Shereen Shermak, our COO, and Joe Chan, our CTO, who have an extensive track record of scaling ventures and building products. We will be the first to provide clinicians and drug developers with a solution that characterizes drug effects and optimizes neurological care.”

Shereen (COO) is a serial startup operator and an Entrepreneur-In-Residence at Harvard Business School. She previously co-founded Nth Party and Launch Angels which were both acquired. Joe (CTO) was previously Head of Engineering at Valo, and before that was the Director of Machine Learning at PathAI. Joe has an extensive software engineering background across many companies including Google for over a decade. 

Dr. William Dauer, the inaugural Director of the Peter O’Donnell Jr. Brain Institute and a Professor of Neurology and Neuroscience at UT Southwestern Medical Center, acclaimed for his research in Parkinson’s disease, weighed in on what a future with DANNCE will look like: “I’m excited for the day when DANNCE is incorporated into clinical practice. Over more than two decades of practicing medicine, I’ve come to recognize the limitations of relying on human judgment to evaluate movement disorders. An objective, quantifiable and easy-to-use method of movement assessment would be valuable for patient care and empower future research.”

We look forward to helping DANNCE leverage our visual tech domain expertise, decades of experience building businesses and our expert network in proactive healthcare.


This article was written in collaboration with Ash Cleary, an associate at LDV Capital.


The Age of New Medicines: How AI is Empowering & Disrupting the Discovery of Proteins, Biologics, Therapeutics & Materials

The Age of New Medicines: How AI is Empowering & Disrupting the Discovery of Proteins, Biologics, Therapeutics & Materials

Meet Dr. Molly Gibson – Co-Founder and Chief Strategy & Innovation Officer at Generate:Biomedicines, Origination Partner at Flagship Pioneering. LDV Capital's Founder & General Partner Evan Nisselson discussed with Molly how AI and machine learning empower and disrupt the scientific process across life sciences, biotech, advanced materials and more.

If you missed our 10th Annual LDV Vision Summit, this is your chance to watch the video or read our shortened & lightly edited transcript.

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Meta’s Matt Uyttendaele on AI for Material Discovery

Meta’s Matt Uyttendaele on AI for Material Discovery

Matt Uyttendaele is the director of the AI for Chemistry group at Meta. His group applies machine learning to material discovery for several applications: clean hydrogen, sorbents for direct air capture, and next-generation displays. In 2024, we were honored to have him speak at our Annual General Meeting about a new application of AI that he has been working on for the last few years and how it relates to his career in visual technologies.

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Max Blacker Joins LDV Capital As an Investment Analyst

Max Blacker Joins LDV Capital As an Investment Analyst

We are honored to have a fantastic LDV team and community of experts that help us filter, review and advise our portfolio teams that are building valuable businesses powered by visual technologies and AI.

We are thrilled to announce the addition of Max Blacker to our LDV team. We were impressed with his communication style, thoughtful approach and problem-solving skills.

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LDV Capital's Annual General Meeting 2024: The Visual Tech & AI Experts Building The Future

LDV Capital's Annual General Meeting 2024: The Visual Tech & AI Experts Building The Future

Our Annual General Meetings (AGM) are exclusive, invite-only events for LDV Capital LPs, portfolio companies, LDV experts and special guests. We are thrilled to share a glimpse of our most recent AGM in New York City, giving you a unique opportunity to see what usually happens behind closed doors.

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120+ Women Spearheading Advances in Visual Tech and AI

120+ Women Spearheading Advances in Visual Tech and AI

Since 2012, we have been showcasing brilliant women whose work in visual tech and AI is reshaping business and society. In 2020, we started our “Women Leading Visual Tech” series. We are thrilled to showcase an expanded list of women behind many of the technological innovations that we experience today. Their contributions are extremely valuable to our ecosystem and the world. Our initial list consists of 121 names placed in alphabetical order. It features experts in machine vision, pattern recognition and generative models for digitizing the real world, as well as leaders in quantum hardware, nanophotonics and semiconductors which is the foundation for all the visual tech and AI progress.

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Visual Tech Advancements in Life Sciences & Biotech Paving the Way for Longer and Healthier Lives

Visual Tech Advancements in Life Sciences & Biotech Paving the Way for Longer and Healthier Lives

As the biotech industry heavily relies on data filtering, analysis, and sharing, visual technologies play a critical role in detecting and imaging biological systems. This paves the way for the future of life sciences tools, enabling next-generation therapeutics, biomanufacturing, and longevity. At our 10th Annual LDV Vision Summit earlier this year, a panel of experts delved into these topics and explored various critical aspects shaping the future of biotechnology. Check out their insights.

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Thank You For Celebrating Our 10th Anniversary LDV Vision Summit With Us!

Thank You For Celebrating Our 10th Anniversary LDV Vision Summit With Us!

We at LDV Capital celebrated our 10th LDV Vision Summit Anniversary! People from over 30 countries were part of our premier global gathering in visual tech & AI. We were thrilled to welcome speakers from Sequoia Capital, Wellville, Generate:Biomedicines, DCVC Bio, Princeton University, Stanford University, University of California, Nobias Therapeutics, Snap, Future Ventures, Meta, Axios and more. Two of our LDV Capital portfolio companies presented as well: Synthesia and Sonus Microsystems.

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Roelof Botha of Sequoia Says 'To Be Successful in This Business, You Have to Be Contrarian and Right'

Roelof Botha of Sequoia Says 'To Be Successful in This Business, You Have to Be Contrarian and Right'

Join our 10th Annual LDV Vision Summit on March 21 and witness the fireside chat between LDV Capital’s Evan Nisselson and Roelof Botha, Managing Partner and Steward of Sequoia Capital. Roelof has spent over 20 years building companies in Silicon Valley. He began within the walls of nascent PayPal and led the company through both its IPO in early 2002 and the subsequent acquisition by eBay. Roelof joined Sequoia in 2003 to help founders build enduring businesses. In 2017, he assumed leadership of Sequoia Capital's US/Europe business and became a Steward of the Sequoia Partnership. Roelof is a Director of 23andMe, Block, Ethos, Inside.com, Landis, mmhmm, MongoDB, Natera, Pendulum Therapeutics, and Unity Technologies, and recently led Sequoia's investment in Meeno. Previously, he was a Director of companies that include YouTube, Tumblr, Xoom, Eventbrite, and Evernote. He also led Sequoia's investment in Instagram.

Roelof and Evan will discuss trends and early-stage investment opportunities in businesses leveraging visual technologies and AI.

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Partnering with Sonus Microsystems to Deliver the Next-Gen Ultrasound For Remote Diagnostic Imaging

Partnering with Sonus Microsystems to Deliver the Next-Gen Ultrasound For Remote Diagnostic Imaging

We are thrilled to partner and invest in the brilliant Sonus Microsystems team developing and commercializing a novel and proprietary ultrasound technology that utilizes polymer MEMS sensors to send and receive ultrasonic waves. They are ushering in a new era of ultrasound by commercializing high-performance, custom-designed linear and matrix array transducers for emerging applications in ultrasound imaging.

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The Age of New Medicines: How AI is Empowering & Disrupting the Discovery of Proteins, Biologics, Therapeutics & Materials

The Age of New Medicines: How AI is Empowering & Disrupting the Discovery of Proteins, Biologics, Therapeutics & Materials

On March 21, at our 10th Annual LDV Vision Summit, Evan Nisselson, Founder and General Partner at LDV Capital, will speak with Dr. Molly Gibson – Co-Founder and Chief Strategy and Innovation Officer at Generate:Biomedicines. They will discuss how AI and machine learning empower and disrupt the scientific process across life sciences, biotech, advanced materials, and more. This will have a tremendous impact on business and society. 

In the lead-up to the Summit, Evan had the privilege of asking Dr. Gibson a few questions.

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​Over 10 Years of Insights on Visual Technologies & AI From Leaders ​a​t DeepMind, Sequoia Capital, Meta, Union Square Ventures,​ Snap and More​

​Over 10 Years of Insights on Visual Technologies & AI From Leaders ​a​t DeepMind, Sequoia Capital, Meta, Union Square Ventures,​ Snap and More​

As we approach our 10th Summit anniversary on March 21, 2024, we decided to go down memory lane and spotlight the exceptional fireside chat speakers LDV Capital's Evan Nisselson has had the privilege to witness and interview over the years. These leaders come from companies such as DeepMind, Sequoia Capital, Union Square Ventures, Meta, Spark Capital, FirstMark, Universal Pictures, Greylock Partners, Snap, First Round Capital, OpenWater and more.

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“The Difference Is – Now The Whole World Is Paying Attention To AI,” Says Prof. Serge Belongie

“The Difference Is – Now The Whole World Is Paying Attention To AI,” Says Prof. Serge Belongie

As we approach the 10th Annual LDV Vision Summit, we thought it fitting to pose a few burning questions to Serge Belongie, a professor of Computer Science at the University of Copenhagen, the head of the Danish Pioneer Centre for Artificial Intelligence and LDV Capital Expert in Residence. We delved into his experiences as a prominent figure in AI and sought his insights on the present landscape of visual technologies. Additionally, we explored his thoughts on the prospects available to researchers aiming to bring their work to market and impact humanity at large.

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LDV Community Helping Entrepreneurs Succeed For 11 Years

LDV Community Helping Entrepreneurs Succeed For 11 Years

Thrilled to present a selection of photos capturing moments from our recent invite-only "Happy Hour" event, held in New York City. This event brought together outstanding technology innovators, serial entrepreneurs, deep tech researchers, and investors from within the vibrant New York tech ecosystem.

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Tackling the Climate Crisis by Detecting, Verifying & Classifying Wildfires in Real-Time With the Help of AI

Tackling the Climate Crisis by Detecting, Verifying & Classifying Wildfires in Real-Time With the Help of AI

The climate crisis is resulting in an increased frequency and intensity of natural disasters, and society needs new tools to be able to cope and adapt. Sonia Kastner is the CEO & founder of Pano AI, the leader in wildfire early detection and intelligence. Pano combines advanced hardware, AI and computer vision to automatically detect, verify and classify wildfire events in real-time. 

At our 9th Annual LDV Vision Summit, Sonia shared how visual technologies are at the crux of disaster mitigation solutions to help tackle the climate crisis.

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